Honokiol
SIGMA/H4914 - ≥98% (HPLC), powder
Synonym: 5,3′-Diallyl-2,4′-dihydroxybiphenyl; NSC 293100
CAS Number: 35354-74-6
Empirical Formula (Hill Notation): C18H18O2
Molecular Weight: 266.33
MDL Number: MFCD00016674
Linear Formula: C18H18O2
Product Type: Chemical
| antibiotic activity spectrum | Gram-positive bacteria |
| neoplastics | |
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C18H18O2/c1-3-5-13-7-9 |
| InChI key | FVYXIJYOAGAUQK-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| Quality Level | 100  |
| SMILES string | Oc1ccc(cc1CC=C)-c2cc(CC=C |
| solubility | DMSO: 36 mg/mL |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Honokiol has been used: • to study its effects on plasmid hSirt3102-399 deacetylation activity • as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1) • to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner • for intracerebroventricular (ICV) cannulation |
| Biochem/physiol Actions: | Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| General description: | Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia. |
| Packaging: | 10, 25 mg in glass bottle |
| Symbol |   GHS05,GHS09 |
| Signal word | Danger |
| Hazard statements | H318 - H411 |
| Precautionary statements | P273 - P280 - P305 + P351 + P338 - P391 - P501 |
| Hazard Codes | Xi |
| Risk Statements | 41 |
| Safety Statements | 26-39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |