Cytochrome P450 3A4 human
SIGMA/H5042 - recombinant, expressed in E. coli
Synonym: Cytochrome P450, purified, soluble; 1,4-cineole 2-exo-monooxygenase; Albendazole sulfoxidase; CYP3A3; CYP3A4; Cytochrome P450 NF-25; Cytochrome P450-PCN1
CAS Number: 9035-51-2
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | 3.5—25 mg protein/mL (Bradford) |
| biological source | human |
| concentration | 3.5-25 mg protein/mL (protein) |
| 50-150 nmol/mL (P450) | |
| 6-14 nmol/mg protein (specific content) | |
| description | purified, soluble |
| form | liquid |
| mol wt | 57318.7 g/mol |
| NCBI accession no. | NP_059488.2   |
| Quality Level | 200 |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| solubility | water: soluble |
| specific activity | 12-200 units/mg protein |
| storage temp. | −70°C |
| technique(s) | cell based assay: suitable |
| Application: | Cytochrome P450 3A4 human has been used in circular dichroism analysis. |
| Biochem/physiol Actions: | Cytochrome P450 3A4 (CYP3A4) is one of the isoforms of cytochrome P450 (P450s). Cytochrome P450s (P450s) plays a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds, and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.CYP3A4 mRNA expression is upregulated in pediatric Crohn’s disease. Moreover, it provides high tolerance against herbicides such as mefenacet, amiprofos-methyl, pyributicarb, norflurazon, trifluralin, pendimethalin, chlorotoluron, and chloroacetamides. |
| General description: | Research area: IMMUNO AND CKS Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract. |
| Other Notes: | One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C. |
| Other Notes: | Supplied as purified soluble proteins, rather than microsomal preparations. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 3.5—25 mg protein/mL (Bradford) |
| activity | specific activity: 12-200 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |