Hygromycin B solution from Streptomyces hygroscopicus

SIGMA/H5527 - ≥60% (HPLC), 45-60 mg/mL in H₂O, γ-irradiated

Synonym: Hygromycin b; Hygrovetine

CAS Number: 31282-04-9
Empirical Formula (Hill Notation): C₂₀H₃₇N₃O₁₃
Molecular Weight: 527.52
MDL Number: MFCD06795479
Linear Formula: C₂₀H₃₇N₃O₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-H5527-250MG	250 mg	$466.00 1/EA		Add To Favorites
45-H5527-500MG	500 mg	$795.00 1/EA		Add To Favorites
45-H5527-1G	1 g	$1480.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	viruses
biological source	Streptomyces hygroscopicus
color	yellow-brown to orange
concentration	≥60% (HPLC)
	45-60 mg/mL in H₂O
InChI	1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
InChI key	GRRNUXAQVGOGFE-XKIAHZFYSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O
sterility	γ-irradiated
storage temp.	2-8°C

Application:	Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.
Biochem/physiol Actions:	Mode of action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation. Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.
Disclaimer:	Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.
General description:	Chemical structure: aminoglycoside
Preparation Note:	This product is a solution that is =60% (HPAE), 45-60 mg/mL in H₂O, and γ-irradiated .

Symbol	GHS05,GHS06,GHS08
Signal word	Danger
Hazard statements	H301 + H311 - H318 - H330 - H334
Precautionary statements	P260 - P280 - P284 - P301 + P310 - P305 + P351 + P338 - P310
Hazard Codes	T+
Risk Statements	26/27/28-41-42/43
Safety Statements	23-26-28-36/37/39-45
RIDADR	UN2810 - class 6.1 - PG 1 - PAX forbidden - Toxic, liquids, orga
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51102829

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