8-Hydroxy-2′-deoxyguanosine

SIGMA/H5653 - ≥98% (TLC)

Synonym: 8-Oxo-7,8-dihydro-2′-deoxyguanosine; 8-Oxo-dG

CAS Number: 88847-89-6
Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₅
Molecular Weight: 283.24
MDL Number: MFCD00210311
Linear Formula: C₁₀H₁₃N₅O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-H5653-1MG	1 mg	$104.00 1/EA		Add To Favorites
45-H5653-5MG	5 mg	$344.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
InChI	1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
InChI key	HCAJQHYUCKICQH-UHFFFAOYSA-N
Quality Level	200
SMILES string	O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
storage temp.	2-8°C

Application:	8-Hydroxy-2′-deoxyguanosine has been used: • as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection • as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement • as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo • as a standard for LC/MS/MS analysis
Biochem/physiol Actions:	A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis
Biochem/physiol Actions:	The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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