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17α-Hydroxyprogesterone

SIGMA/H5752 - ≥95%

Synonym: 17α-Hydroxy-4-pregnene-3,20-dione; 4-Pregnen-17α-ol-3,20-dione

CAS Number: 68-96-2
Empirical Formula (Hill Notation): C21H30O3
Molecular Weight: 330.46
EC Number: 200-699-4
MDL Number: MFCD00003659
Linear Formula: C21H30O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H5752-5G 5 g
 $111.00
1/EA		 Add To Favorites
45-H5752-25G 25 g
 $421.00
1/EA		 Add To Favorites
ATR-IR Spectra for 17α-Hydroxy-4-pregnene-3,20-dione.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H5752-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H5752-5G

 

assay ≥95%
biological source synthetic (organic)
form powder
InChI 1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
InChI key DBPWSSGDRRHUNT-CEGNMAFCSA-N
Quality Level 200 
shipped in ambient
SMILES string [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O
solubility chloroform: 50 mg/mL, clear, colorless to light yellow
sterility non-sterile
storage temp. room temp
Application: 17α-Hydroxyprogesterone has been used:
• for titration against ovarian S9 protein in thin-layer chromatography
• as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures
• as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)
Biochem/physiol Actions: 17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).
General description: 17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.
Packaging: 5, 25 g in poly bottle
Purity ≥95%
Storage Temp. room temp
UNSPSC 51111800

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