[Tyr(SO₃H)⁶³]-Hirudin Fragment 54-65

SIGMA/H6894 - ≥95% (HPLC)

CAS Number: 109528-49-6
Empirical Formula (Hill Notation): C₆₆H₉₃N₁₃O₂₈S
Molecular Weight: 1548.58
MDL Number: MFCD00076564
Linear Formula: C₆₆H₉₃N₁₃O₂₈S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-H6894-.1MG	0.1 mg	$184.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C66H93N13O28S/c1-5-34(4)55(78-59(95)41(21-26-53(88)89)71-56(92)38(18-23-50(82)83)72-61(97)44(29-35-10-7-6-8-11-35)77-63(99)46(31-54(90)91)69-49(81)32-67)65(101)79-27-9-12-47(79)64(100)73-40(20-25-52(86)87)57(93)70-39(19-24-51(84)85)58(94)76-45(30-36-13-15-37(16-14-36)107-108(104,105)106)62(98)75-43(28-33(2)3)60(96)74-42(66(102)103)17-22-48(68)80/h6-8,10-11,13-16,33-34,38-47,55H,5,9,12,17-32,67H2,1-4H3,(H2,68,80)(H,69,81)(H,70,93)(H,71,92)(H,72,97)(H,73,100)(H,74,96)(H,75,98)(H,76,94)(H,77,99)(H,78,95)(H,82,83)(H,84,85)(H,86,87)(H,88,89)(H,90,91)(H,102,103)(H,104,105,106)
InChI key	CKXMQSIWBKKXGT-UHFFFAOYSA-N
Quality Level	200
SMILES string	CCC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(O)=O)NC(=O)CN)C(=O)N2CCCC2C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(Cc3ccc(OS(O)(=O)=O)cc3)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(O)=O
storage temp.	−20°C

Amino Acid Sequence:	Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln
Application:	[Tyr(SO₃H)⁶³]-hirudin fragment 54-65 has been used to study the effect of thrombin in presence of leupeptin. It is also used to study the effect of hirudin peptide on the thrombin-rHCII (recombinant heparin cofactor II)-L444R (leucine 444 to arginine) complex separation.
Biochem/physiol Actions:	Hirudin fragment that binds to the regulatory exosite I on thrombin and the regulatory proexosite I on prothrombin.
Biochem/physiol Actions:	Hirudin fragment that binds to the regulatory exosite I on thrombin and the regulatory proexosite I on prothrombin. The interaction with thrombin prevents the thrombin-induced activation of clotting factor V. The interaction with prothrombin inhibits the formation of thrombin by factor Xa in the presence of factor Va.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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