Histamine
SIGMA/H7125 - ≥97.0%
Synonym: 2-
CAS Number: 51-45-6
Empirical Formula (Hill Notation): C5H9N3
Molecular Weight: 111.15
EC Number: 200-100-6
MDL Number: MFCD00005210
Linear Formula: C5H9N3
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H7125-5G
| assay | ≥97.0% |
| bp | 167 °C/0.8 mmHg (lit.) |
| InChI | 1S/C5H9N3/c6-2-1-5-3-7-4- |
| InChI key | NTYJJOPFIAHURM-UHFFFAOYSA |
| mp | 83-84 °C (lit.) |
| Quality Level | 200  |
| SMILES string | NCCc1c[nH]cn1 |
| storage temp. | −20°C |
| Application: | Histamine has been used: • to stimulate regulated cellular secretion • in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry • to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium |
| Biochem/physiol Actions: | Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator. |
| Biochem/physiol Actions: | Endogenous H1 and H2 histamine receptor agonist; H1 activation mobilizes Ca2+; H2 activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator. |
| Biochem/physiol Actions: | Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control. |
| General description: | Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter. |
| Packaging: | 1, 5, 25 g in glass bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H315 - H317 - H319 - H334 - H335 |
| Precautionary statements | P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-42/43 |
| Safety Statements | 22-26-36/37 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.0% |
| bp | 167 °C/0.8 mmHg (lit.) |
| mp | 83-84 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352116 |