Histamine dihydrochloride
SIGMA/H7250 - ≥99% (TLC), powder
Synonym: 2-
CAS Number: 56-92-8
Empirical Formula (Hill Notation): C5H9N3 · 2HCl
Molecular Weight: 184.07
EC Number: 200-298-4
MDL Number: MFCD00012703
Linear Formula: C5H9N3 · 2HCl
Product Type: Chemical
| assay | ≥99% (TLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C5H9N3.2ClH/c6-2-1-5-3 |
| InChI key | PPZMYIBUHIPZOS-UHFFFAOYSA |
| mp | 249-252 °C (lit.) |
| Quality Level | 200  |
| SMILES string | Cl[H].Cl[H].NCCc1c[nH]cn1 |
| storage temp. | 2-8°C |
| Application: | Histamine dihydrochloride has been used: • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP) • to determine its level in fish using HPLC (high performance liquid chromatography) • to assess the tracheal response to antigens in guinea-pigs |
| Biochem/physiol Actions: | Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator. |
| Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients. |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 10, 25 g in poly bottle |
| Packaging: | 5 g in glass bottle |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H317 - H319 - H334 - H335 |
| Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 22-26-36/37/39-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (TLC) |
| mp | 249-252 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352116 |