Hyaluronic acid sodium salt from bovine vitreous humor

SIGMA/H7630

Synonym: Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

CAS Number: 9067-32-7
MDL Number: MFCD01773053
Linear Formula: (C₁₄H₂₁NaNO₁₁)_n
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-H7630-10MG	10 mg	$377.00 1/EA	Add To Favorites
45-H7630-50MG	50 mg	$1570.00 1/EA	Add To Favorites

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This image depicts SKU: H7630-50MG

Properties
Descriptions
Safety Info.
Basic Data

biological source	bovine (vitreous humor)
color	white
form	powder
InChI	1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key	YWIVKILSMZOHHF-QJZPQSOGSA-N
Quality Level	200
SMILES string	[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
solubility	water: ~5 g/L
storage temp.	−20°C

Application:	Hyaluronic acid sodium salt from bovine vitreous humor has been used: • as a component for the generation of artificial synovial fluid • to investigate its role in inducing oxidative stress and interleukin 8(IL-8) production in human nasal RPMI 2650 cells • to test its effect on B cell proliferation • as a substrate in neuraminidase assay of morbilliviruses virus
Biochem/physiol Actions:	High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Biochem/physiol Actions:	Hyaluronic acid (HA) is abundantly present in the bovine vitreous humor. It corresponds to a molecular weight of 69293.9Da and has an isoelectric pH of 5.82. Bovine HA has high levels of endotoxins and it polydisperse with DNA and RNA contaminants. The enzyme HA synthases at the plasma membrane (HASs) aids in the synthesis of circulatory HA. HA is implicated in many physiological processes including inflammation, immune regulation, adhesion, embryo development and tumor progression.
Other Notes:	To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Packaging:	10, 50 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352201

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