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Heparan sulfate sodium salt from bovine kidney

SIGMA/H7640

Synonym: Heparitin sulfate sodium salt

CAS Number: 57459-72-0
MDL Number: MFCD00131294
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H7640-1MG 1 mg
 $221.00
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45-H7640-5MG 5 mg
 $773.00
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45-H7640-10MG 10 mg
 $1360.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H7640-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H7640-1MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H7640-5MG

 

Quality Level 200 
storage temp. 2-8°C
Application: Heparan sulfate sodium salt from bovine kidney has been used:
• to investigate its effect on proliferation of B cells
• to monitor its role on eye development in E5 embryonic cells
• to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot
Biochem/physiol Actions: Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion
Biochem/physiol Actions: Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.
Packaging: 1, 5, 10 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 12352200

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