HBcAg core human
SIGMA/H8909 - ~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli
Synonym: Hepatitis B virus core antigen
MDL Number: MFCD02264925
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| concentration | ~1 mg/mL |
| mol wt | 18 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| UniProt accession no. | G9G988  |
| Biochem/physiol Actions: | HBcAg core human is a capsid protein of hepatitis B virus (HBV). It acts as a viral factor for HBV clearance. HBcAg is implicated in viral replication. |
| Biochem/physiol Actions: | Hepatitis B virus core antigen (HBcAg) is a positive control for human HBV antibodies.In humans with chronic HBV (hepatitis B virus) infection, cytotoxic effects of blood T lymphocytes can be suppressed by incubating cells with antibodies against hepatitis B core antigen (HBcAg). The antigen can also work as a T-cell independent antigen in athymic mice. However, it is an efficient immunogen, resulting in T-cell activation and increased anti-HBc levels. High cytoplasmic/membranous expression of HBcAg is associated with increased liver inflammation. |
| General description: | amino acids 1-183 of HBV core antigen. |
| Physical form: | Solution in 50% glycerol, 7.5 mM phosphate buffer, pH 7.2, 75 mM NaCl. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |