Hypoxanthine
SIGMA/H9377 - ≥99.0%
Synonym: 6-Hydroxypurine
CAS Number: 68-94-0
Empirical Formula (Hill Notation): C5H4N4O
Molecular Weight: 136.11
EC Number: 200-697-3
MDL Number: MFCD00005725
Linear Formula: C5H4N4O
Product Type: Chemical
FT-IR Spectra for 6-Hydroxypurine.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H9377-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H9377-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H9377-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H9377-25G
| assay | ≥99.0% |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C5H4N4O/c10-5-3-4(7-1- |
| InChI key | FDGQSTZJBFJUBT-UHFFFAOYSA |
| mp | >300 °C (lit.) |
| Quality Level | 300  |
| SMILES string | O=C1NC=Nc2nc[nH]c12 |
| solubility | formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow |
| Application: | Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies. |
| Application: | Hypoxanthine has been used: • to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia • as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells) • as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-viol |
| Biochem/physiol Actions: | Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position. It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases. |
| Packaging: | 1, 5, 25, 100 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% |
| mp | >300 °C (lit.) |
| UNSPSC | 41106305 |