22(R)-Hydroxycholesterol

SIGMA/H9384 - ≥98%

Synonym: 22α-Hydroxycholesterol; 5-Cholestene-3β,22(R)-diol; 5-Cholestene-3β,22[R]-diol

CAS Number: 17954-98-2
Empirical Formula (Hill Notation): C₂₇H₄₆O₂
Molecular Weight: 402.65
MDL Number: MFCD00070042
Linear Formula: C₂₇H₄₆O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-H9384-1MG	1 mg	$122.00 1/EA	Add To Favorites
45-H9384-5MG	5 mg	$451.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
form	powder
InChI	1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
InChI key	RZPAXNJLEKLXNO-GFKLAVDKSA-N
Quality Level	200
shipped in	ambient
SMILES string	[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])[C@H](C)[C@H](O)CCC(C)C
storage temp.	room temp

Application:	Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.
Biochem/physiol Actions:	22(R)-Hydroxycholesterol is an intermediate of the pregnenolone synthesis pathway from cholesterol. It reported has neuroprotective properties and protects the neurons against β-amyloid-induced cell death. 22(R)-Hydroxycholesterol acts as the ligand of liver X receptors that act as sensors of sterol concentration and regulates the fatty acid metabolism.
Packaging:	1, 5 mg in glass bottle
Preparation Note:	22(R)-Hydroxycholesterol yield clear, colorless solution in chloroform.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	room temp
UNSPSC	12352211

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