Anti-OASL antibody produced in rabbit
SIGMA/HPA001474 - affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-59 kDa 2′→5′-Oligoadenylate synthetase-like protein antibody produced in rabbit; Anti-TRIP-14 antibody produced in rabbit; Anti-Thyroid receptor-interacting protein 14 antibody produced in rabbit; Anti-p59 OASL antibody produced in rabbit; Anti-p59OASL antibody produced in rabbit
Product Type: Chemical
Immunofluorescence Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm and cytosol.
Western Blotting Western blot analysis in human cell line HDLM-2.
Prestige Antibodies® Highly characterized and Enhanced Validated antibodies
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| immunogen sequence | EVLDAVRTVEEFLRQEHFQGKRGLD |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: 0.04-0.4 μg/mL |
| immunofluorescence: 0.25-2 μg/mL | |
| UniProt accession no. | Q15646  |
| Application: | Anti-OASL antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige . |
| Biochem/physiol Actions: | OASL (2′-5′-oligoadenylate synthetase-like) is a 59kDa protein that is an atypical member of the OAS family as it does not possess the characteristic 2′-5′ oligoadenylate synthetase activity. It exhibits an antiviral effect against the single-stranded RNA viruses, such as, picornavirus, encephalomyocarditis virus. It inhibits hepatitis C viral replication in vitro. OASL interacts with the transcriptional repressor Methyl CpG-binding protein 1 (MBD1) upon interferon stimulation. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| Immunogen: | 59 kDa 2′→5′-Oligoadenylate synthetase-like protein recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST83083 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |