Anti-PREX1 antibody produced in rabbit
SIGMA/HPA001927 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-P-Rex1 protein antibody produced in rabbit; Anti-
Product Type: Chemical
Western Blotting JOURNAL CITATION: P-Rex1 cooperates with PDGFRβ: to drive cellular migration in 3D microenvironments. By: Campbell, A. D., Lawn, S., et al. in PLoS One, 2013. PubMed ID: 23382862 Image collected and cropped by CiteAb from the following publication, (http://dx.plos.org/10.1371/journal.pone.0053982), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunohistochemistry Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neurons.
Immunohistochemistry Immunohistochemical staining of human hippocampus shows moderate cytoplasmic positivity in neuronal cells.
Immunohistochemistry Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in leukocytes.
Immunohistochemistry Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in lymphoid cells.
Immunohistochemistry Immunohistochemical staining of human kidney shows no cytoplasmic positivit as expected.
Immunofluorescence Immunofluorescent staining of human cell line A-431 shows localization to cytosol and vesicles.
Prestige Antibodies® Highly characterized and Enhanced Validated antibodies
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| application(s) | research pathology |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| enhanced validation | orthogonal RNAseq Learn more about Antibody Enhanced Validation  |
| form | buffered aqueous glycerol solution |
| immunogen sequence | CAGQCILKVNGSNVMNDGAPEVLEH |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: 0.25-2 μg/mL |
| immunohistochemistry: 1:200-1:500 | |
| UniProt accession no. | Q8TCU6  |
| Application: | Rabbit polyclonal PREX1 antibody is used to tag phosphatidylinositol 3,4,5-trisphosphate-depen |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | P-Rex1 protein is a Rac-GEF, guanine nucleotide exchange factor, for the RHO family of GTPases, connecting Gβγ and phosphatidylinositol 3-kinase signaling to Rac activation. P-Rex1 promotes membrane ruffling and links mTOR signaling to Rac activation of cell migration. |
| General description: | Rabbit polyclonal PREX1 antibody reacts with human phosphatidylinositol 3,4,5-trisphosphate-depen |
| Immunogen: | Phosphatidylinositol 3,4,5-trisphosphate-depen |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST86391 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |