Anti-SSTR2 antibody produced in rabbit
SIGMA/HPA007264 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-SRIF-1 antibody produced in rabbit; Anti-SS2R antibody produced in rabbit; Anti-Somatostatin receptor type 2 antibody produced in rabbit
MDL Number: MFCD02097419
Product Type: Chemical
By Recombinant Expression Western blot analysis in control (vector only transfected HEK293T lysate) and sSTR2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY400438).
Immunohistochemistry Immunohistochemical staining of human cerebral cortex shows positivity in neuropil.
Immunohistochemistry Immunohistochemical staining of human kidney shows strong positivity in cells in tubules.
Immunohistochemistry Immunohistochemical staining of human duodenum shows strong membranous positivity in glandular cells.
Immunohistochemistry Immunohistochemical staining of human pancreas shows moderate to strong membranous positivity in islets of Langerhans.
Immunofluorescence Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
Western Blotting Western blot analysis in human cerebral cortex tissue.
Prestige Antibodies® Highly characterized and Enhanced Validated antibodies
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| enhanced validation | recombinant expression Learn more about Antibody Enhanced Validation  |
| form | buffered aqueous glycerol solution |
| immunogen sequence | DNFKKSFQNVLCLVKVSGTDDGERS |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: 0.04-0.4 μg/mL |
| immunofluorescence: 0.25-2 μg/mL | |
| immunohistochemistry: 1:50-1:200 | |
| UniProt accession no. | P30874  |
| Application: | Anti-SSTR2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige . |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper) |
| Biochem/physiol Actions: | SSTR2 (Somatostatin receptor 2) is a regulatory peptide widely distributed in tissues. It is involved in several cellular functions including, neuroendocrine and exocrine secretions, and proliferation. In neuronal tissues, it interacts with the inhibitory G-proteins in both the chambers, presynaptic and postsynaptic, to control the synaptic responses. It has the ability to control the proliferation of both normal and neoplastic cells. It is abundantly present at the plasma membrane of several tumorous cells such as pancreatic, gastrointestinal, breast carcinoma, neuroblastomas etc. Thus, SSTR2 has been proved as a potential prognostic marker for certain malignancies. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | SSTR2 (Somatostatin receptor 2) is a novel multi-domain protein belonging to a family of cytoskeletal anchoring proteins. It consists of six N-terminal ankyrin repeats followed by SH3 and PDZ domains, several proline-rich regions, and a C-terminal sterile α region. |
| Immunogen: | Somatostatin receptor type 2 recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST70183 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |