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Anti-GALNT5 antibody produced in rabbit

SIGMA/HPA009035 - Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-GalNAc-T5

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-HPA009035-100UL 100 µL
$667.00
1/EA
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Immunohistochemistry Immunohistochemical staining of human stomach shows strong cytoplasmic positivity with a granular pattern in glandular cells.
Immunofluorescence Immunofluorescent staining of human cell line BJ shows localization to cytosol and the Golgi apparatus.
Prestige Antibodies® Highly characterized and Enhanced Validated antibodies

 

antibody form affinity isolated antibody
antibody product type primary antibodies
biological source rabbit
clone polyclonal
conjugate unconjugated
form buffered aqueous glycerol solution
immunogen sequence MKPPLRGHGKGAWGKENVRKTEESVLKVEVDLDQTQRERKMQNALGRGKVVPLWHPAHLQTLPVTPNKQKTDGRGTKPEASSHQGTPKQTTAQGAPKTSFIAAKGTQVVKISVHMGRVSLKQEPR
product line Prestige Antibodies® Powered by Atlas Antibodies
Quality Level 100 
shipped in wet ice
species reactivity human
storage temp. −20°C
target post-translational modification unmodified
technique(s) immunofluorescence: 0.25-2 μg/mL
  immunohistochemistry: 1:200-1:500
UniProt accession no. Q7Z7M9 
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project  and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols   and other useful information.
Biochem/physiol Actions: GALNT5 (N-acetylgalactosaminyltransferase 5) glycosylates restricted types of substrates. It is capable of interacting with Golgi proteins, by projecting its catalytic domain in the lumen of the Golgi complex. It might play a role in maintaining the structure of gastric mucosa, and less differentiated gastric tumor tissues show low expression of this protein. Its low expression is linked with TNM classification, and functions as an independent prognostic marker for poor outcome in gastric cancer patients. In breast cancer, missense mutation in this gene results in the loss of enzymatic function of this GALNT5 protein. This gene is also up-regulated in hepatoblastomas when compared to the expression in differentiated livers.
Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits: Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.
General description: GALNT5 (N-acetylgalactosaminyltransferase 5) is a highly tissue specific protein. It predominantly localizes to the cytoplasm of gastric epithelial and gastric cancer cells. This gene localizes to human chromosome 2q24.
Immunogen: polypeptide N-acetylgalactosaminyltransferase 5
Legal Information: Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Corresponding Antigen APREST71963
Physical form: Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352203

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