Anti-BTN3A3 antibody produced in rabbit
SIGMA/HPA011871 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-BTF3; Anti-BTN3.3
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of human spleen shows strong membranous positivity in cells in red pulp.
Immunohistochemistry Immunohistochemical staining of human tonsil shows moderate membranous positivity in non-germinal center cells.
Immunohistochemistry Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.
Immunohistochemistry Immunohistochemical staining of human prostate shows moderate membranous positivity in glandular cells.
Prestige Antibodies® Highly characterized and Enhanced Validated antibodies
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| immunogen sequence | IALSRETEREREMKEMGYAATEQEI |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:20- 1:50 |
| UniProt accession no. | O00478  |
| Application: | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. |
| Biochem/physiol Actions: | BTN3A3 (butyrophilin, subfamily 3, member A3) is a member of the butyrophilin (BTN) family with B7 family homology. It consists of IgV-like exoplasmic domain followed by another exoplasmic IgC-like domain. There is a protein binding SPRY/PRY B30.2 region at the cytoplasmic domain. It is expressed on endothelial cells, in the membrane layer surrounding milk fat-secreting droplet from mammary epithelial cells, immune cells, and on some tumor cell lines. It is a potent regulator of the immune system. Study shows the involvement of BTN3A3 in the proliferation of CD4+ and CD8+ and in the cytokine secretion by T-cells. It has also been reported that it may function as a co-stimulatory molecule on CD4+ T cells and NK (Natural Killer) cells. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| Immunogen: | Butyrophilin subfamily 3 member A3 precursor recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST71798 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |