Anti-STAR antibody produced in rabbit
SIGMA/HPA023644 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1
Synonym: Anti-NET29; Anti-STARD1; Anti-TMPIT; Anti-steroidogenic acute regulatory protein
Product Type: Chemical
Enhanced Validation-By Independent Antibodies Immunohistochemical staining of human adrenal gland, kidney, lymph node and testis using Anti-STAR antibody HPA023644 (A) shows similar protein distribution across tissues to independent antibody HPA027318 (B).
Enhanced Validation-Orthogonal RNAseq Confirmation Immunohistochemistry analysis in human adrenal gland and skeletal muscle tissues using HPA023644 antibody. Corresponding STAR RNA-seq data are presented for the same tissues.
Immunohistochemistry Immunohistochemical staining of human testis shows strong positivity in mitochondria in Leydig cells.
Immunohistochemistry Immunohistochemical staining of human adrenal gland shows strong positivity in mitochondria in glandular cells.
Immunohistochemistry Immunohistochemical staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry Immunohistochemical staining of human kidney using Anti-STAR antibody HPA023644.
Immunohistochemistry Immunohistochemical staining of human lymph node using Anti-STAR antibody HPA023644.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| enhanced validation | independent orthogonal RNAseq Learn more about Antibody Enhanced Validation  |
| form | buffered aqueous glycerol solution |
| immunogen sequence | QDNGDKVMSKVVPDVGKVFRLEVVV |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:200-1:500 |
| UniProt accession no. | P49675  |
| Application: | Anti-STAR antibody produced in rabbit has been used to detect StAR in Paraffin-embedded adrenal samples using immunohistochemistry. |
| Biochem/physiol Actions: | Steroidogenic acute regulatory protein (StAR) is essential for the transfer of cholesterol to mitochondria for adrenal and gonadal steroidogenesis. StAR gene analysis can help in the diagnosis of lipoid congenital adrenal hyperplasia (LCAH). It is also identified that activins A,B,AB downregulates StAR and thereby reduces the production of progesterone in human granulosa cells. Hypoxia mediated upregulation of StAR stimulates the synthesis of aldosterone in pulmonary artery endothelial cells which contributes to pulmonary vascular fibrosis. Activation of StAR helps in prevention of atherosclerotic cardiovascular disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | Steroidogenic acute regulatory protein is located on human chromosome 8p11.2. |
| Immunogen: | steroidogenic acute regulatory protein recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST76259 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |