Anti-STAB2 antibody produced in rabbit
SIGMA/HPA026871 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-190 kDa hyaluronan receptor for endocytosis; Anti-FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Anti-FEEL-2; Anti-Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; Anti-Hyaluronan receptor for endocytosis; Anti-Stabilin-2
Product Type: Chemical
Enhanced Validation-Orthogonal RNAseq Confirmation Immunohistochemistry analysis in human spleen and cerebral cortex tissues using HPA026871 antibody. Corresponding STAB2 RNA-seq data are presented for the same tissues.
Immunohistochemistry Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in endothelial cells.
Immunohistochemistry Immunohistochemical staining of human liver shows moderate to strong cytoplasmic positivity in hepatic sinusoid cells.
Immunohistochemistry Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in endothelial cells.
Immunohistochemistry Immunohistochemical staining of human cerebral cortex shows low expression as expected.
Immunofluorescence Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| enhanced validation | orthogonal RNAseq Learn more about Antibody Enhanced Validation  |
| form | buffered aqueous glycerol solution |
| immunogen sequence | VVLEEKLLKNDLHNGMHRETMLGFS |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: 0.25-2 μg/mL |
| immunohistochemistry: 1:500-1:1000 | |
| UniProt accession no. | Q8WWQ8  |
| Application: | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. |
| Biochem/physiol Actions: | The hyaluronan receptor for endocytosis (HARE) or stabilin-2 functions as a mammalian endocytic clearance receptor for hyaluronic acid (HA), heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides. HARE/Stab2 facilitates binding of lymphocyte to sinusoidal endothelium by interacting with αMβ2 and α5β5 integrins. The encoded protein mediates phagocytosis of bacteria and apoptotic cells displaying cell surface phosphatidylserine. In mice, Stab-2 might assist in separating hyaluronan from the lymph or the blood circulation through the network of endothelial sinuses. The protein also exhibits scavenger receptor activity. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | The Stabilin-2 (STAB2) gene with 69 exons spanning 180kbp is mapped to human chromosome 12. Stabilin-2, also known as fasciclin, EGF-like, laminin-type EGF-like, and link domain-containing scavenger receptor-2 (FEEL-2) or hyaluronan receptor for endocytosis (HARE), is a large receptor containing 2551 amino acids belonging to the family of fasciclin-like hyaluronan receptor homologues. STAB2 transcript is expressed in spleen, bone marrow and liver. |
| Immunogen: | Stabilin-2 Precursor recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST71958 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |