Anti-IP6K1 antibody produced in rabbit
SIGMA/HPA040825 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-IHPK1; Anti-Inositol hexakisphosphate kinase 1; Anti-KIAA0263
Product Type: Chemical
Immunofluorescence Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center and cytosol.
Western Blotting Western blot analysis in human cell line PC-3.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| immunogen sequence | DSDGYINLVAYPYVESETVEQDDTT |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: 0.04-0.4 μg/mL |
| immunofluorescence: 0.25-2 μg/mL | |
| UniProt accession no. | Q92551  |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. • Western Blotting (1 paper) .• immunofluorescence. • fluorescence-activated cell sorting (FACS). |
| Biochem/physiol Actions: | Inositol hexakisphosphate kinase 1 (IP6K1) is involved in the synthesis of diphosphoinositol pentakisphosphate. It interacts with cullin–RING ubiquitin ligase-4 (CRL4) and has a role in DNA homologous recombination repair. In addition, IP6K1 is also implicated in chromatin modifications and spermatogenesis. Elevated expression or mutation of IP6K1 is associated with the pathogenesis of type 2 diabetes mellitus and crohn′s disease. IP6K1 plays a vital role in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement and Golgi maintenance. IP6K1 controls DNA repair and cell death by mediating disassembly of the cullin-RING ubiquitin ligase 4 (CRL4)-COP9 signalosome (CSN) complex. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | Inositol hexakisphosphate kinase (IP6K1) is encoded by the gene mapped to human chromosome 3p21.31. The encoded protein belongs to the family of inositol hexakisphosphate (IP6) proteins and is widely expressed. |
| Immunogen: | inositol hexakisphosphate kinase 1 recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST79496 |
| Physical form: | Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |