Anti-SPRED1 antibody produced in rabbit
SIGMA/HPA042193 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-FLJ33903; Anti-PPP1R147
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of human gallbladder shows moderate cytoplasmic positivity in glandular cells.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| immunogen sequence | GQPGLDIQSRSMEYVQRQISKECGS |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:20- 1:50 |
| UniProt accession no. | Q7Z699  |
| Application: | All Prestige Antibodies® Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. |
| Application: | Anti-SPRED1 antibody produced in rabbit has been used in immunohistochemistry. |
| Biochem/physiol Actions: | Sprouty related EVH1 domain containing 1 (SPRED1) acts as a negative regulator of Ras by hindering the phosphorylation of Raf. The encoded protein negatively regulates mast cell activation and high affinity immunoglobulin E receptor (FcεRI)-mediated cytokine production, which is controlled by miR126. SPRED1 also plays a vital role in neural and behavioral plasticity. Mutation in the gene leads to legius syndrome and neurofibromatosis type 1 (NF1)-like syndrome (NFLS). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | Sprouty related EVH1 domain containing 1 (SPRED1) is encoded by the gene mapped to human chromosome 15q14. The encoded protein belongs to the SPROUTY/SPRED family of proteins. SPRED1 is predominantly expressed in hematopoietic cells. |
| Immunogen: | sprouty-related, EVH1 domain containing 1 recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST81524 |
| Physical form: | Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |