Anti-CDX2 antibody produced in rabbit
SIGMA/HPA049580 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody
Synonym: CDX3
Product Type: Chemical
Immunofluorescence Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| immunogen sequence | PGPLRSVPEPLSPVSSLQASVPGSV |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: 0.25-2 μg/mL |
| UniProt accession no. | Q99626  |
| Application: | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. |
| Application: | Anti-CDX2 antibody recognises CDX2 protein. |
| Biochem/physiol Actions: | Caudal type homeobox 2 (CDX2) plays a key role during early developmental stages by providing positional information for gastrointestinal tract, especially the midgut region. Cdx2 promotes proliferation and differentiation of intestinal epithelial cells. Cdx2 has tumour suppression function in colon cancer cells. Cdx2 expression level is found to decrease as the cancer advances from dysplasia to advanced gastric cancer. Abnormal amplification and upregulation of Cdx2 leads to colorectal cancer. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | Caudal type homeobox 2 (CDX2) is a member of caudal-related homeobox transcription factor gene family. Cdx2 is homologous to Drosophila developmental gene caudal. The Cdx2 gene is located on the human chromosome on 13q12.2. It is prominently produced in the intestine. |
| Immunogen: | caudal type homeobox 2 |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST91202 |
| Physical form: | Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |