Insulin solution from bovine pancreas

SIGMA/I0516 - 10 mg/mL insulin in 25 mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

Synonym: Bovine insulin; Cell culture grade insulin

CAS Number: 11070-73-8
MDL Number: MFCD00131380
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-I0516-5ML	5 mL	$141.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

biological source	bovine
concentration	10 mg/mL insulin in 25 mM HEPES, pH 8.2
form	solution
impurities	endotoxin, tested
InChI	1S/2C97H151N25O34S4/c21-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h213-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1
InChI key	XYPANFGXFLOTDK-CJLNJPJHSA-N
pH	7.9-8.5
product line	BioReagent
Quality Level	400
shipped in	ambient
SMILES string	SC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@H](CC)C)C(C)C)CCC(=O)O)CCC(=O)N)CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4ccc(cc4)O)C(=O)N[
sterility	sterile-filtered
storage temp.	2-8°C
technique(s)	cell culture \| mammalian: suitable
	single cell analysis: suitable
UniProt accession no.	P01317

Application:	Insulin solution from bovine pancreas has been used: • to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth factor I (IGF-I), and progesterone (P4) in pubertal beef heifers • to study the insulin responsiveness of the placenta during pregnancy complications using primary human trophoblast cells and placental villous explants • to study the effect of insulin receptor signaling dendritic spine density in neonatal mouse hippocampal neurons in vitro
Biochem/physiol Actions:	Insulin is a major glucose-lowering hormone, insufficiency of which causes hyperglycemia observed in type 2 diabetes.
Biochem/physiol Actions:	Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.
Physical form:	stable 2-8 °C

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352209

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