IWP-2
SIGMA/I0536 - ≥98% (HPLC)
Synonym: N-
CAS Number: 686770-61-6
Empirical Formula (Hill Notation): C22H18N4O2S3
Molecular Weight: 466.60
MDL Number: MFCD04457599
Linear Formula: C22H18N4O2S3
Product Type: Chemical
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This image depicts I0536-5MG.
This image depicts I0536-5MG.
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C22H18N4O2S3/c1-13-7-8 |
| InChI key | WRKPZSMRWPJJDH-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cc1ccc2nc(NC(=O)CSC3=NC4= |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | IWP-2 has been used to treat the cell lines L-Wnt-3a and L-Wnt-5a, to demonstrate the inhibitory effect of IWP-2. It has also been used as a Wnt signaling inhibitor to treat WT and Gja1Jrt/+ stromal cells to confirm that, theWnt/β-catenin signaling pathway pathway was not involved in the increased marker expression by Gja1Jrt/+ osteoblasts. |
| Biochem/physiol Actions: | IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. |
| Biochem/physiol Actions: | IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWP-2 inhibits Wnt production. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352202 |