Interleukin-2 Soluble Receptor α human
SIGMA/I0779 - >97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym: CD25; IL-2 sRα; Tac antigen
MDL Number: MFCD01323736
Product Type: Chemical
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| assay | >97% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | 36 kDa by SDS-PAGE |
| packaging | pkg of 5 μg |
| potency | 0.5-1.0 mg per mL ED50 |
| Quality Level | 200  |
| recombinant | expressed in NSO cells |
| storage temp. | −20°C |
| UniProt accession no. | P01589  |
| Analysis Note: | The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e. |
| Biochem/physiol Actions: | Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >97% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |