Inosine 5′-triphosphate trisodium salt

SIGMA/I0879 - ≥95%

Synonym: ITP

CAS Number: 35908-31-7
Empirical Formula (Hill Notation): C₁₀H₁₂Na₃N₄O₁₄P₃
Molecular Weight: 574.11
MDL Number: MFCD00084678
Linear Formula: C₁₀H₁₂Na₃N₄O₁₄P₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-I0879-50MG	50 mg	$76.40 1/EA	Add To Favorites
45-I0879-100MG	100 mg	$128.00 1/EA	Add To Favorites
45-I0879-500MG	500 mg	$424.00 1/EA	Add To Favorites
45-I0879-1G	1 g	$699.00 1/EA	Add To Favorites

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This image depicts SKU: I0879-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
InChI	1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
InChI key	RIERCUPIZLBNFQ-UHFFFAOYSA-N
Quality Level	200
shipped in	dry ice
SMILES string	[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
storage temp.	−20°C

Application:	Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.
Application:	Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.
Biochem/physiol Actions:	Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.
Packaging:	1 g in poly bottle
Packaging:	50, 100, 500 mg in poly bottle
Preparation Note:	Prepared from Bacterial ATP

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	41106305

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