Iodoacetamide
SIGMA/I1149 - BioUltra
Synonym: 2-Iodoacetamide; Monoiodoacetamide; alpha-Iodoacetamide
CAS Number: 144-48-9
Empirical Formula (Hill Notation): C2H4INO
Molecular Weight: 184.96
EC Number: 205-630-1
MDL Number: MFCD00008028
Linear Formula: ICH2CONH2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I1149-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I1149-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I1149-25G
| anion traces | chloride (Cl-): ≤0.05% |
| sulfate (SO42-): ≤0.05% | |
| assay | ≥99% (NMR) |
| biological source | synthetic (organic) |
| cation traces | Al: ≤0.0005% |
| Ca: ≤0.0005% | |
| Cu: ≤0.0005% | |
| Fe: ≤0.0005% | |
| K: ≤0.005% | |
| Mg: ≤0.0005% | |
| Na: ≤0.05% | |
| NH4+: ≤0.05% | |
| Pb: ≤0.001% | |
| Zn: ≤0.0005% | |
| form | powder |
| impurities | ≤0.0005% Phosphorus (P) |
| ≤0.1% Insoluble matter | |
| InChI | 1S/C2H4INO/c3-1-2(4)5/h1H |
| InChI key | PGLTVOMIXTUURA-UHFFFAOYSA |
| mp | 92-95 °C (lit.) |
| product line | BioUltra |
| Quality Level | 300  |
| SMILES string | NC(=O)CI |
| solubility | H2O: 0.5 M, clear, colorless |
| storage temp. | 2-8°C |
| Application: | Iodoacetamide has been used: • in protein digestion for proteomic analysis • to alkylate protein samples • in the denaturation of cow′s milk allergens, β-lactoglobulin (BLG) and α-lactalbumin (ALA) |
| Biochem/physiol Actions: | Iodoacetamide (IAA) is used to inhibit glycolysis due to its ability to irreversibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphat |
| Biochem/physiol Actions: | Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease. |
| Packaging: | 5, 25, 100 g in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H315 - H317 - H319 - H335 |
| Precautionary statements | P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 25-42/43-53 |
| Safety Statements | 22-36/37-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥99% (NMR) |
| mp | 92-95 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |