Icariin

SIGMA/I1286 - ≥94% (HPLC)

Synonym: 4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside

CAS Number: 489-32-7
Empirical Formula (Hill Notation): C₃₃H₄₀O₁₅
Molecular Weight: 676.66
MDL Number: MFCD00210516
Linear Formula: C₃₃H₄₀O₁₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-I1286-100MG	100 mg	$178.00 1/EA	Add To Favorites
45-I1286-1G	1 g	$1030.00 1/EA	Add To Favorites

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This image depicts SKU: I1286-100MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
assay	≥94% (HPLC)
color	light yellow to yellow
InChI	1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
InChI key	TZJALUIVHRYQQB-XLRXWWTNSA-N
Quality Level	100
SMILES string	COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(CC=C(C)C)c4O2
solubility	DMSO: 50 mg/mL, clear, colorless to dark yellow
storage temp.	room temp

Application:	Icariin has been used: • in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats • to test its analgesic effects on lower back pain (LBP) in rats • as a potential treatment in osteoporosis condition in rats • to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes • as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells
Biochem/physiol Actions:	Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.
Biochem/physiol Actions:	Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.
General description:	Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.
Packaging:	1 g in poly bottle
Packaging:	100 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥94% (HPLC)
Storage Temp.	room temp
UNSPSC	12352205

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