L-N5-(1-Iminoethyl)ornithine hydrochloride
SIGMA/I134 - ≥95% (HPLC)
Synonym: L-NIO hydrochloride; L-Ornithine ψ-acetamidine hydrochloride
CAS Number: 852173-80-9
Empirical Formula (Hill Notation): C7H15N3O2 · xHCl
Molecular Weight: 173.21 (free base basis)
MDL Number: MFCD00153817
Linear Formula: C7H15N3O2 · xHCl
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C7H15N3O2.ClH/c1-5(8)1 |
| InChI key | JIBZSGQTCBWUKL-RGMNGODLSA |
| mol wt | calculated mol wt 173.22 g/mol |
| Quality Level | 100  |
| SMILES string | CC(NCCC[C@H](N)C(O)=O)=N. |
| solubility | H2O: 2 mg/mL, clear (warmed) |
| storage condition | desiccated |
| under inert gas | |
| storage temp. | −20°C |
| Application: | L-N5-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect. It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed. |
| Biochem/physiol Actions: | A potent irreversible inhibitor of nitric oxide synthase. |
| Packaging: | 1, 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |