Irinotecan hydrochloride

SIGMA/I1406 - topoisomerase inhibitor

Synonym: (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester; CPT-11; [1,4′-Bipiperidine]-1′-carboxylic acid

CAS Number: 100286-90-6
Empirical Formula (Hill Notation): C₃₃H₃₈N₄O₆ · HCl
Molecular Weight: 623.14
MDL Number: MFCD01862255
Linear Formula: C₃₃H₃₈N₄O₆ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-I1406-50MG	50 mg	$227.00 1/EA	Add To Favorites
45-I1406-250MG	250 mg	$855.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I1406-250MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
biological source	plant (Fructus camptothecae)
form	powder
InChI	1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
InChI key	GURKHSYORGJETM-WAQYZQTGSA-N
SMILES string	Cl.CCc1c2CN3C(=O)C4=C(C=C3c2nc5ccc(OC(=O)N6CCC(CC6)N7CCCCC7)cc15)[C@@](O)(CC)C(=O)OC4
solubility	DMSO: 50 mg/mL
storage temp.	2-8°C

Application:	Irinotecan hydrochloride has been used: • in combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells. • in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids. • as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.
Biochem/physiol Actions:	The anticancer agent, irinotecan, is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1 (UGT1A1).
Biochem/physiol Actions:	The anticancer agent, irinotecan, is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1 (UGT1A1). It proves useful in radiation treatment of tumors by sensitizing tissue to radiation damage.
Biochem/physiol Actions:	The anticancer agent, irinotecan, is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase.
Packaging:	50, 250 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352204

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