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ITX3

SIGMA/I1411 - ≥98% (HPLC)

Synonym: 2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one

CAS Number: 347323-96-0
Empirical Formula (Hill Notation): C22H17N3OS
Molecular Weight: 371.45
MDL Number: MFCD02629172
Linear Formula: C22H17N3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I1411-5MG 5 mg
 $101.00
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45-I1411-25MG 25 mg
 $271.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form powder
InChI 1S/C22H17N3OS/c1-14-12-16(15(2)24(14)17-8-4-3-5-9-17)13-20-21(26)25-19-11-7-6-10-18(19)23-22(25)27-20/h3-13H,1-2H3/b20-13+
InChI key SJMYMKPBODEZSH-DEDYPNTBSA-N
Quality Level 100 
SMILES string Cc1cc(C=C2Sc3nc4ccccc4n3C2=O)c(C)n1-c5ccccc5
solubility DMSO: ≥4 mg/mL
storage temp. room temp
Biochem/physiol Actions: ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.
Biochem/physiol Actions: ITX3 is a specific inhibitor of endogenous TrioN activity; selective cell active inhibitor of the Trio/RhoG/Rac1 pathway.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GTP Binding Proteins (Low Molecular Weight)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352202

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