Interleukin-8 human
SIGMA/I1645 - recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: IL-8, CXCL8, neutrophil chemotactic factor
MDL Number: MFCD00131404
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | ≤1 EU/μg (LAL test) |
| mol wt | monomer 8.9 kDa ((77 aa)) |
| packaging | pkg of 10 μg |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P10145  |
| Application: | Interleukin-8 (IL-8) human has ben used to: • measure neutrophil chemotoxis • study the uptake of apoptotic cells by meningothelial cells • study the effect of IL-8 on expression and secretion of urocortin-1 by human umbilical vein endothelial cells |
| Biochem/physiol Actions: | Interleukin-8 (IL-8) was formerly called monocyte-derived neutrophil chemotactic factor. It belongs to the chemokine α or C-X-C family. Like other members of this family, the mature form of IL-8 has four cysteine residues and the first two cysteine residues are separated by glutamine. IL-8 shows chemotactic activity in vitro for T cells, neutrophils and basophils. Mutation in IL-8 can increase risk to acute pancreatitis. |
| Biochem/physiol Actions: | Interleukin-8 (IL-8), formerly called monocyte-derived neutrophil chemotactic factor, belongs to the chemokine α or C-X-C family. The mature form of IL-8 has 4 cysteine residues, as do the other members of the chemokine family and the first two cysteine residues are separated by glutamine. Mature human IL-8 consists of 72 amino acids with a molecular mass of 8.9 kDa. IL-8 exhibits chemotactic activity in vitro for T cells, basophils, as measured by enzymes including myeloperoxidase, α-mannosidase and β-glucuronidase. IL-8 is an angiogenic factor. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution containing 10 mM sodium phosphate, pH 7.5 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |