Interleukin-3 human
SIGMA/I1646 - IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: Interleukin-3 human; hIL-3; hIL-3; IL-3
MDL Number: MFCD00147276
Product Type: Chemical
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| assay | ≥97% (HPLC and SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | ≤0.1 EU/μg |
| mol wt | 15 kDa |
| packaging | pkg of 10 and 50 μg |
| potency | ≤1.0 ng/mL ED50/EC50 |
| quality | endotoxin tested |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P08700  |
| Analysis Note: | The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells. |
| Biochem/physiol Actions: | Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor. |
| Biochem/physiol Actions: | Interleukin-3 is a multifunctional protein produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and induce IgG secretion from activated B cells. |
| Physical form: | Lyophilized with no additives. Sterile filtered through a 0.2 μm filter. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC and SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |