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IU1

SIGMA/I1911 - ≥98% (HPLC)

Synonym: 1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone

CAS Number: 314245-33-5
Empirical Formula (Hill Notation): C18H21FN2O
Molecular Weight: 300.37
MDL Number: MFCD01917473
Linear Formula: C18H21FN2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I1911-5MG 5 mg
 $157.00
1/EA		 Add To Favorites
45-I1911-25MG 25 mg
 $601.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white to light brown
form powder
InChI 1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
InChI key JUWDSDKJBMFLHE-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC1=CC=C(N2C(C)=CC(C(CN3CCCC3)=O)=C2C)C=C1
solubility DMSO: >10 mg/mL
storage temp. 2-8°C
Application: IU1 has been used for the inhibition of Ubiquitin Specific Peptidase 14 (USP14) in human neuroblastoma cells (SH-SY5Y) and in ubiquitin-rhodamine hydrolysis plate assay.
Biochem/physiol Actions: IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome.
Biochem/physiol Actions: IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. The proteasome mediates the cellular degradation of oxidized, damaged and misfolded proteins which, if not removed, accumulate and become toxic to cells. Proteins targeted for proteasomal degradation are first ubiquitinated, with longer length ubiquitin chains interacting more strongly with the proteasome. Deubiquitinating enzymes (DUBs) such as USP14 interfere with the degradation process. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 41
Safety Statements 61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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