Isocitric Dehydrogenase (NADP) from porcine heart
SIGMA/I2002 - Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
Synonym: threo-Ds-Isocitrate: NADP+ oxidoreductase; ICDH; IDH
CAS Number: 9028-48-2
EC Number: 200-289-5
MDL Number: MFCD00131420
Product Type: Chemical
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| composition | Protein biuret |
| form | buffered aqueous glycerol solution |
| quality | ≤ 0.2% of main activity is obtained with NAD as cofactor. |
| Quality Level | 200  |
| shipped in | wet ice |
| specific activity | 3-20 units/mg protein |
| storage temp. | 2-8°C |
| type | Type IV |
| Application: | Isocitric dehydrogenase (IDH) has been used:• for in vitro activity assay to study the effects of thorium on citric acid cycle enzymes in the mitochondrial respiration pathway • as a standard to measure the impact of temperature on nicotinamide diphosphate (NADP)-IDH activity • in isocitrate assay |
| Biochem/physiol Actions: | Isocitrate dehydrogenase (IDH) is a homodimeric enzyme and participates in several processes such as adapting to hypoxia, histone demethylation, and DNA modification. This enzyme has three isoforms like IDH1, IDH2, and IDH3. |
| Other Notes: | One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37 °C. |
| Physical form: | Solution in 50% glycerol in EDTA buffer salts, pH 6.0 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| activity | specific activity: 3-20 units/mg protein |
| Storage Temp. | 2-8°C |
| Enzyme Commission (EC) Number | 1.1.1.42 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |