Monoclonal Anti-Insulin antibody produced in mouse
SIGMA/I2018 - clone K36AC10, ascites fluid
Synonym: Insulin Antibody; Insulin Antibody - Monoclonal Anti-Insulin antibody produced in mouse
MDL Number: MFCD00164675
Product Type: Chemical
Immunohistochemistry JOURNAL CITATION: Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding. By: Absood, A., Gandomani, B., et al. in PLoS One, 2013. PubMed ID: 23408938 Image collected and cropped by CiteAb from the following publication, (http://dx.plos.org/10.1371/journal.pone.0054351), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunohistochemistry JOURNAL CITATION: Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding. By: Absood, A., Gandomani, B., et al. in PLoS One, 2013. PubMed ID: 23408938 Image collected and cropped by CiteAb from the following publication, (http://dx.plos.org/10.1371/journal.pone.0054351), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunohistochemistry Staining of formalin-fixed, paraffin-embedded human pancreas tissue sections with 1:1,000 Monoclonal Anti-Insulin Clone: K36AC10 (Cat. No. I2018) using biotin/ExtrAvidin®-Peroxidase.
| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | K36AC10, monoclonal |
| conjugate | unconjugated |
| contains | 15 mM sodium azide |
| isotype | IgG1 |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | dot blot: suitable |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas | |
| radioimmunoassay: suitable | |
| UniProt accession no. | P01308  |
| Application: | Monoclonal Anti-Insulin antibody produced in mouse has been used in immunoblotting assay and ELISA. |
| Application: | Monoclonal Anti-Insulin antibody produced in mouse was used in ELISA-based protein pin array assay to study the interactions between human αB crystalline and insulin. It was used for flow cytometric analysis of rat white blood cells and mast cells. |
| Biochem/physiol Actions: | Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways. |
| Biochem/physiol Actions: | Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways. Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. Insulin is known to stimulate cell division. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The antibody reacts specifically against insulin by RIA and immunocytochemistry. It exhibits cross-reactivity with human proinsulin. The antibody binds to insulin with an affinity constant of 8.8 × 109 M-1 in RIA. |
| General description: | The insulin gene is mapped to human chromosome 11p15.5. |
| Hazard Codes | Xn |
| Risk Statements | 21/22 |
| Safety Statements | 36/37-60 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |