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Irbesartan

SIGMA/I2286 - ≥98% (HPLC), powder

Synonym: 2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one; Avapro; BMS-186295; SR-47436

CAS Number: 138402-11-6
Empirical Formula (Hill Notation): C25H28N6O
Molecular Weight: 428.53
MDL Number: MFCD00864464
Linear Formula: C25H28N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I2286-10MG 10 mg
 $107.00
1/EA		 Add To Favorites
45-I2286-50MG 50 mg
 $415.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)
InChI key YOSHYTLCDANDAN-UHFFFAOYSA-N
originator Bristol-Myers Squibb
  Sanofi Aventis
Quality Level 100 
SMILES string CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5
solubility DMSO: >25 mg/mL
storage temp. 2-8°C
Application: Irbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue. It may be used to test its effect on allergic asthma in rat and mice mast cells.
Biochem/physiol Actions: Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity. It also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and possesses anti-inflammatory properties. Irbesartan shows protective cardiovascular effects and provides protection against chronic glomerulonephritis.
Features and Benefits: This compound is featured on the Angiotensin Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Bristol-Myers Squibb  and Sanofi Aventis . To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here .
General description: Irbesartan comprises bipentyl-tetrazole side chain. It is an imidazole derivative with high bioavailability and is metabolized by the enzyme cytochrome P450 2C9 isoenzyme in liver to be majorly eliminated by oxidation and glucuronidation.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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