Interleukin-1β from rat
SIGMA/I2393 - IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: IL-1β; Interleukin-1β from rat; Lymphocyte activating factor
MDL Number: MFCD01094098
Product Type: Chemical
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| assay | ≥98% (SDS-PAGE and HPLC) |
| biological source | rat |
| form | lyophilized powder |
| impurities | <0.1 EU/μg |
| mol wt | 17.3 kDa |
| packaging | pkg of 10 and 50 μg |
| potency | 0.01-0.1 ng/mL ED50/EC50 |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | Q63264  |
| Analysis Note: | The biological activity is measured in a cell proliferation assay using murine D10S cells. |
| General description: | Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cells and lymphocytes, which then proliferate and secrete interleukin-2.1 IL-1 is primarily released from stimulated macrophages and monocytes, but is also released from several other cell types,2 and is thought to play a key role in inflammatory and immune responses.3 Other synonyms for IL-1 include: Endogenous Pyrogen (EP), Mitogenic Protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFH), B cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF).4 The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence. Recombinant rat IL-1β is a 17.3 kDa protein containing 153 amino acid residues. |
| Physical form: | Lyophilized from a 0.2 μm filtered buffered solution. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE and HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |