Isocitrate Dehydrogenase 1 (NADP+) human
SIGMA/I2411 - recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)
Synonym: IDH1; Isocitrate Dehydrogenase Cytoplasmic
CAS Number: 9028-48-2
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| concentration | ≥0.30 mg/mL protein (Bradford) |
| form | buffered aqueous glycerol solution |
| mol wt | 47.6 kDa |
| NCBI accession no. | NM_005896   |
| Quality Level | 200 |
| recombinant | expressed in Sf9 cells |
| relevant disease(s) | cancer (lung) |
| shipped in | dry ice |
| storage temp. | −70°C |
| Application: | Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer . |
| Biochem/physiol Actions: | Human Isocitrate Dehydrogenase (IDH1), also known as oxalosuccinate decarboxylase, is a full length amino acid with a C-terminal FLAG-tag and is expressed in Sf9 cells via a baculovirus expression system. IDH1 expression has been correlated with poor survival of non-small cell lung cancer. IDH1 promotes tumor growth . |
| General description: | Human Isocitrate Dehydrogenase (IDH1), also known as oxalosuccinate decarboxylase, full length [amino acids 1-414 (end)] with C-terminal FLAG-tag, expressed in Sf9 cells via a baculovirus expression system. |
| Physical form: | Solution in 45 mM Tris-HCl, 124 mM NaCl, 2.4 mM KCl, 90 μg/ml FLAG peptide, 3 mM DTT, and 10% glycerol at pH 8.0. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 1.1.1.42 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |