Insulin-like Growth Factor-II human
SIGMA/I2526 - IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: IGF-II
MDL Number: MFCD00241895
Product Type: Chemical
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| assay | ≥98% (SDS-PAGE and HPLC) |
| biological source | human |
| form | lyophilized powder |
| impurities | ≤0.1 EU/μg |
| mol wt | 7.5 kDa |
| packaging | pkg of 50 μg |
| pkg of 5X50 μg | |
| potency | ≤2.0 ng/mL ED50 |
| quality | endotoxin tested |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01344  |
| Analysis Note: | The biological activity is measured by a cell proliferation assay using mouse FDC-P1 |
| Biochem/physiol Actions: | IGF-II, also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. IGF-II binds to the IGF-II receptor, IGF-I receptor, and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-I receptor. However, during embryogenesis the roles of both IGF-II receptor and IR may be significant in promoting normal growth. |
| Biochem/physiol Actions: | Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution with no additives. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE and HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |