Interleukin-2 human
SIGMA/I2644 - IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: IL-2; Interleukin-2; Interleukin-2 human; T-cell growth factor; hIL-2; hIL-2; Interleukin-2; T-cell growth factor
MDL Number: MFCD00165721
Product Type: Chemical
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| biological source | human |
| form | lyophilized powder |
| impurities | ≤1 EU/μg |
| mol wt | 15.5 kDa |
| packaging | pkg of 10 μg |
| pkg of 5X10 μg | |
| potency | ≤700 EC50 |
| quality | endotoxin tested |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P60568  |
| Analysis Note: | The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells. |
| Application: | Interleukin-2 human has been used: • in the stimulation of natural killer cells • to study its ability to stimulate lymphocyte growth and prevent apoptosis • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus |
| Biochem/physiol Actions: | Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. |
| Biochem/physiol Actions: | Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation. |
| General description: | Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor. |
| Packaging: | 10 μg in poly bottle |
| Physical form: | Lyophilized, 0.2 μm filtered, no additives. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |