Ibotenic acid
SIGMA/I2765 - ~95%, solid
Synonym: α-Amino-3-hydroxy-5-isoxazoleacetic acid
CAS Number: 2552-55-8
Empirical Formula (Hill Notation): C5H6N2O4
Molecular Weight: 158.11
MDL Number: MFCD00069294
Linear Formula: C5H6N2O4
Product Type: Chemical
| assay | ~95% |
| color | white |
| form | solid |
| InChI | 1S/C5H6N2O4/c6-4(5(9)10)2 |
| InChI key | IRJCBFDCFXCWGO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | NC(C(O)=O)C1=CC(=O)NO1 |
| solubility | 0.1 M HCl: 4.7 mg/mL |
| 0.1 M NaOH: 10.7 mg/mL | |
| H2O: 1 mg/mL, clear, colorless (with sonication) |
| Application: | Ibotenic acid has been used as a neurontoxin in rats. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons. |
| Application: | Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes. |
| Biochem/physiol Actions: | Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT). It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality. |
| Biochem/physiol Actions: | Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin. |
| Biochem/physiol Actions: | Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species. |
| Disclaimer: | Hygroscopic |
| Packaging: | 1, 5, 10, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 + P330 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 3462 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ~95% |
| UNSPSC | 12352209 |