Interleukin-1α human
SIGMA/I2778 - IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: IL-1α; hIL-1α.; Interleukin-1α human; Lymphocyte activating factor
MDL Number: MFCD00164814
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥98% (SDS-PAGE and HPLC) |
| biological source | human |
| form | lyophilized powder |
| mol wt | ~17 kDa |
| packaging | pkg of 2 and 10 μg |
| quality | endotoxin tested |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01583  |
| Analysis Note: | The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S. |
| Application: | Interleukin-1α (IL-1α) has been used: • to study its effects on human colorectal adenocarcinoma cells • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells • to pre-stimulate human THP-1 monocytes |
| Biochem/physiol Actions: | Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin. |
| General description: | Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1. |
| Packaging: | 2 μg in serum bottle |
| Physical form: | Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P261 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE and HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |