Polyinosinic–polycytidylic acid potassium salt
SIGMA/I3036 - γ-irradiated
Synonym: Poly (I:C); Poly(I) • Poly(C)
CAS Number: 31852-29-6
MDL Number: MFCD00131983
Product Type: Chemical
Polyinosinic–polycytidylic acid sodium salt unit structure.
| assay | ≥99% (TLC) |
| composition | , 8-12% UV |
| Quality Level | 200  |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine. |
| Other Notes: | Double-stranded homopolymer. |
| Packaging: | Package size based on polynucleotide content |
| Physical form: | 10% Poly (I:C) with sodium chloride and sodium phosphate buffer salts |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |