IMD-0354
SIGMA/I3159 - ≥98% (HPLC), solid
Synonym: N-
CAS Number: 978-62-1
Empirical Formula (Hill Notation): C15H8ClF6NO2
Molecular Weight: 383.67
MDL Number: MFCD00218820
Linear Formula: C15H8ClF6NO2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | solid |
| InChI | 1S/C15H8ClF6NO2/c16-9-1-2 |
| InChI key | CHILCFMQWMQVAL-UHFFFAOYSA |
| Quality Level | 100  |
| shipped in | wet ice |
| SMILES string | Oc1ccc(Cl)cc1C(=O)Nc2cc(c |
| solubility | DMSO: >20 mg/mL |
| storage temp. | −20°C |
| Application: | IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts. |
| Biochem/physiol Actions: | IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4] |
| Packaging: | 5, 10 mg in glass bottle |
| Packaging: | Light sensitive. Packaged under nitrogen. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |