Anti-Interleukin-1α antibody produced in goat
SIGMA/I3392 - IgG fraction of antiserum, lyophilized powder
Synonym: Anti-IL-1α
MDL Number: MFCD00165461
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| neutralization: suitable | |
| western blot: suitable | |
| UniProt accession no. | P01582  |
| Application: | Anti-interleukin 1α antibody is suitable for neutralization reactions and the recommended ND50 is 0.04-0.2 μg/ml. The antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for indirect ELISA applications. |
| Biochem/physiol Actions: | The antibody will neutralize the biological activity of recombinant mouse IL-1α, but not recombinant human IL-1α, IL-1β or recombinant mouse IL-1β. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis Anti-interleukin-1α specifically reacts with mouse IL-1α. It does not react with human IL-1α and IL-1β or mouse IL-1β. |
| Immunogen: | recombinant mouse IL-1α. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline pH 7.4, with 5% trehalose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |