Interleukin-17A human
SIGMA/I3525 - ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym: CTLA-8; IL-17
MDL Number: MFCD01094096
Product Type: Chemical
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| assay | ≥98% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).) |
| mol wt | 31 kDa |
| packaging | pkg of 50 μg |
| potency | ≤2.0 ng/mL ED50 |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | Q16552  |
| Analysis Note: | • The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells. • Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg. |
| Biochem/physiol Actions: | IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. |
| Biochem/physiol Actions: | Initially known as CTLA-8; is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system; has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. |
| Physical form: | Lyophilized with no additives. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |