Insulin-Like Growth Factor Binding Protein-2 from mouse
SIGMA/I3657 - ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Synonym: IGFBP-2
MDL Number: MFCD02099094
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | ~35 kDa by SDS-PAGE (reducing) |
| calculated mol wt 29.4 kDa | |
| packaging | pkg of 25 μg |
| potency | 0.125-0.5 mg per mL ED50 |
| Quality Level | 200  |
| recombinant | expressed in NSO cells |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | D3YU40  |
| Analysis Note: | The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells. |
| Biochem/physiol Actions: | During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology. |
| Biochem/physiol Actions: | Exhibits a 2-10 fold higher affinity for IGF II than for IGF I. |
| Biochem/physiol Actions: | IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors. |
| General description: | IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |