Ionomycin calcium salt

SIGMA/I3909 - Ready Made Solution, from Streptomyces conglobatus, 1 mM in DMSO

Synonym: Calcium Ionophore Ionomycin

CAS Number: 56092-82-1
Empirical Formula (Hill Notation): C₄₁H₇₀CaO₉
Molecular Weight: 747.07
EC Number: 200-664-3
MDL Number: MFCD00083634
Linear Formula: C₄₁H₇₀CaO₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-I3909-1ML	1 mL	$360.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
assay	≥98% (HPLC)
biological source	Streptomyces conglobatus
color	colorless
concentration	1 mM in DMSO
InChI	1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key	WKRWUYKLUMMAKG-WYGBAUISSA-L
mode of action	cell membrane \| interferes
mp	18.4 °C
Quality Level	300
shelf life	2 yr
shipped in	wet ice
SMILES string	C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)CC=C[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
solubility	DMSO: 1 mM
storage condition	(Tightly closed. )
storage temp.	−20°C

Application:	Ionomycin finds application in:• Study of calcium signaling and its role in various biological processes • Investigation of intracellular calcium levels, calcium-dependent enzymes, and cellular responses triggered by calcium influx • Induction of a rapid and controlled increase in intracellular calcium levels in cell biology experiments • Elucidation of specific cellular mechanisms and signaling pathways in combination with other substances, such as fluorescent calcium indicators or protein kinase activators Ionomycin has been used: • to induce central demyelination • inhibit adrenal bovine TREK-1 channels • to regulate cell division of mature human B cells
Biochem/physiol Actions:	Ca²⁺ ionophore that is more effective than A23187 as a mobile ion carrier for Ca²⁺.
Biochem/physiol Actions:	Ionomycin is an ionophoric antibiotic that binds Pb2+ and Ca2+, and serves as an effective mobile carrier of both cations. Mode of Action: Facilitates the transfer of calcium ions (Ca2+) across biological membranes Antimicrobial Spectrum: Active against Gram-Positive bacteria
Biochem/physiol Actions:	Ionomycin is an ionophoric antibiotic which binds Pb²⁺ and Ca²⁺, and serves as an effective mobile carrier of both cations. Ionomycin is more effective than A23187 as a mobile ion carrier for Ca²⁺. It is non-fluorescent. It is used to study Ca²⁺ transport across biological membranes and induces apoptotic degeneration of embryonic cortical neurons.
Features and Benefits:	• Ready available solution reduce the need for preparation time • Efficient choice for studying calcium signaling and its role in various biological processes • Allows for rapid and controlled manipulation of intracellular calcium levels • Versatile and widely used in cell biology research
General description:	Ionomycin is a calcium ionophore commonly derived from produced by the bacterium Streptomyces conglobatus, which means that it helps to transport calcium ions across cell membranes. It is a powerful tool for studying calcium signaling and its role in various biological processes, including cell activation, secretion, proliferation, and apoptosis. Ionomycin is commonly used in cell biology experiments to induce a rapid and controlled increase in intracellular calcium levels. This allows to study the downstream effects of calcium signaling pathways, such as the activation of enzymes, the release of hormones, and the changes in gene expression.Ionomycin is also used to investigate the role of calcium in specific cellular processes, such as cell death, immune cell activation, and muscle contraction. For example, ionomycin can be used to induce apoptosis in cancer cells, study the activation of T cells, and investigate the role of calcium in muscle contraction.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .

RIDADR	NA 1993 / PGIII
WGK Germany	WGK 1
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Purity	≥98% (HPLC)
mp	18.4 °C
Storage Temp.	−20°C
UNSPSC	51102829

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